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Updated: Jun 24, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Lateralizations of head-neck cancers are not associated with peripheral asymmetry of cell-mediated immunity
1Department of Ear, Nose, Throat, Medical School, Ataturk University, Erzurum, Turkey.
Abstract:
Earlier studies have reported right-sided lateralization for different organ cancers except breast cancer. In the present study, lateralization of head-neck cancers and their relation with the peripheral cell-mediated immune asymmetry was investigated. The sample was comprised of 42 men and 20 women diagnosed with cancer in the head-neck region. The diagnosis of cancer was made histopathologically. To measure the cell-mediated (type IV) immunity of both forearms, the tuberculin test (PPD test) was used in the subjects previously sensitized by BCG vaccine during the first year of age. Significant right-sided lateralization in men and the significant left-sided lateralization in women were observed in this study. There was no relation between the lateralization of cancer and the asymmetry of tuberculin reaction or the peripheral cell-mediated immune asymmetry.
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