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[ER stress and psychiatric disorders]
1Laboratory Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka, Suita 565-0871, Japan. kudo@psy.med.osaka-u.ac.jp
Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|March 31, 2009
Summary
Endoplasmic reticulum (ER) stress, caused by unfolded proteins, triggers cellular responses and can lead to apoptosis. ER stress is increasingly linked to diseases including bipolar disorder and sleep disturbances.
Area of Science:
- Cellular Biology
- Molecular Biology
- Neuroscience
Context:
- Accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response.
- The unfolded protein response (UPR) involves translation inhibition, chaperone induction, and ER-associated degradation (ERAD).
- Failure to resolve ER stress can result in ER-mediated apoptosis.
Purpose:
- To explore the role of ER stress in various diseases.
- To investigate the specific involvement of ER stress in psychiatric disorders, particularly bipolar disorder.
- To examine the connection between ER stress and sleep disturbances.
Summary:
- ER stress is implicated in conditions like ischemic diseases, viral infections, diabetes, and neurodegenerative disorders.
- Recent findings suggest ER stress is involved in bipolar disorder, with evidence including drug effects, genetic polymorphisms, and disease-related gene induction.
- ER stress has also been linked to the development of sleep disturbances.
Impact:
- Highlights ER stress as a significant factor in diverse pathologies.
- Underscores the potential of targeting ER stress pathways for therapeutic interventions in bipolar disorder and sleep disorders.
- Provides a foundation for further research into the molecular mechanisms connecting ER stress to neurological and psychiatric conditions.
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