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Related Concept Videos

Mortar Properties01:17

Mortar Properties

Mortar properties encompass a range of characteristics crucial for construction and masonry work, including workability, water retention, bond strength, durability, compressive strength, volume change, and appearance. Workability refers to mortar's ability to be easily applied and manipulated without sagging or falling off surfaces, which is important for efficient masonry unit placement and alignment. Water retention is essential to prevent the mortar from losing moisture too quickly to the...
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Design Example: Managing Concrete Workability01:14

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Compaction properties of isomalt.

Gerad K Bolhuis1, Jeffrey J P Engelhart, Anko C Eissens

  • 1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. g.k.bolhuis@rug.nl

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|March 31, 2009
PubMed
Summary
This summary is machine-generated.

Isomalt, a pharmaceutical excipient, shows varied compaction properties. Agglomerated isomalt offers improved flowability and tablet compaction, making it suitable for direct compression applications.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Isomalt is a lesser-known polyol pharmaceutical excipient despite its pharmacopoeia recognition.
  • Understanding its properties is crucial for tablet formulation and direct compaction.

Purpose of the Study:

  • To investigate the compaction properties of different isomalt types for direct tablet compression.
  • To evaluate the impact of particle characteristics (sieving, milling, agglomeration) on isomalt's performance.

Main Methods:

  • Characterization of powder flow, surface area, and density for sieved, milled, and agglomerated isomalt.
  • Tablet compaction simulation to assess compactibility.
  • Lubricant sensitivity testing using magnesium stearate.

Main Results:

  • Sieved isomalt exhibited poor compactibility and high lubricant sensitivity.
  • Milled isomalt showed improved compactibility but poor flow properties.
  • Agglomerated isomalt demonstrated excellent flowability, good compactibility, and low lubricant sensitivity.

Conclusions:

  • Agglomeration of isomalt enhances its suitability as a filler-binder for direct compression.
  • Particle engineering through agglomeration overcomes limitations of milled isomalt.
  • Isomalt's GPS/GPM ratio did not significantly influence compaction properties.