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Updated: Jun 24, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Novel finding of high density of activated mast cells in endometrial polyps
Moamar Al-Jefout1, Kirsten Black2, Lauren Schulke2
1Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, Australia; Royal Prince Alfred Hospital, Missenden Road, Camperdown, Australia; Muta'h Medical Faculty, Muta'h University, Jordan.
Abstract:
Endometrial polyps are benign lesions frequently identified in women with infertility or abnormal uterine bleeding in the reproductive and postmenopausal phases We report the striking observation that the numbers of activated mast cells expressing tryptase are increased more than sevenfold throughout the cycle in endometrial polyps (n = 20) compared with normal endometrium. This novel finding has important implications for growth, development, and symptoms associated with polyps in many different tissues.
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