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Published on: January 7, 2018
Effects of testosterone and metformin on glucose metabolism in endometrium
1Reproductive and Genetic Center, The First Hospital of Peking University, Beijing, People's Republic of China. dr_zl@hotmail.com
Objective:
To investigate the effects of testosterone and metformin on glucose metabolism in endometrium.
Design:
In vitro experiment.
Setting:
Reproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China.
Patient(S):
Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis.
Intervention(S):
Endometrial glandular epithelial cell culture.
Main Outcome Measure(S):
Insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT-4) expression in endometrial glandular epithelial cell.
Result(S):
After the action of testosterone solution, the protein expressions of IRS-1mRNA, IRS-1, and GLUT-4 in endometrial glandular epithelial cells all decreased significantly. Metformin may reverse this effect.
Conclusion(S):
The high androgen levels in patients with polycystic ovary syndrome could induce insulin resistance in endometrial glandular epithelial cell, whereas metformin has an antagonizing effect.
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