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Zearalenone and reproductive function in farm animals
Fiorenza Minervini1, Maria Elena Dell'Aquila2
1Institute of Sciences of Food Production (ISPA), National Research Council (CNR)/ Via G. Amendola 122/O, 70125 Bari, Italy.
International Journal of Molecular Sciences
|March 31, 2009
Summary
Zearalenone mycotoxins in animal feed cause reproductive issues in farm animals. This review covers zearalenone
Area of Science:
- Veterinary Medicine
- Toxicology
- Animal Reproduction
Background:
- Farm animals frequently encounter zearalenone, a mycotoxin prevalent in cereals.
- Clinical reproductive disorders are commonly observed in farm animal species due to mycotoxin exposure.
Purpose of the Study:
- To review the metabolism and mechanistic aspects of zearalenone in farm animals.
- To describe clinical reproductive symptoms and in vitro effects of zearalenone on oocytes and sperm cells.
- To elucidate the role of zearalenone in reproductive failure in farm animals.
Main Methods:
- Literature review of studies on zearalenone metabolism and effects.
- Analysis of in vitro studies on oocyte and sperm cell function.
- Correlation of in vitro findings with in vivo reproductive symptoms.
Main Results:
- Zearalenone exposure impacts semen quality and female reproductive function.
- In vitro studies provide insights into the mechanisms of zearalenone toxicity.
- Understanding these mechanisms helps explain observed in vivo symptoms in farm animals.
Conclusions:
- Zearalenone and its derivatives induce adverse effects on reproductive parameters in farm animals.
- Impaired semen quality and female reproductive function are linked to zearalenone exposure.
- Zearalenone is a significant contributing factor to reproductive failure in livestock.
