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Updated: Jun 24, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
[Is Schilling test necessary for the etiological diagnosis of B12 insufficiency?]
Elias E Mazokopakis1, Christos M Karefilakis, Charis Giannopoulou
1Iroon Polytechniu 38A, Chania 73 132, Crete, Greece. emazokopakis@yahoo.gr
Abstract:
In the following article a comparative evaluation of the tests used for the causative investigation of vitamin B(12) deficiency is presented. Although Schilling test since 2003 is not available in the market, it is considered the gold standard as a functional test of vitamin B(12) absorption, as it not only has a high specificity for the diagnosis of pernicious anaemia but also examines both gastric and intestinal stage of vitamin B(12) absorption. Consequently restoration of Schilling test in the clinical setting is necessary for the etiological diagnosis of B(12) insufficiency at least until a new and better vitamin B(12) absorption test is approved.
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