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Updated: Jun 24, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
Stereotactic biopsies of brain lesions
Manoel Jacobsen Teixeira1, Erich Talamoni Fonoff, Mauricio Mandel
1Departamento de Neurologia, Faculdade de Medicina, Universidade Estadual de São Paulo, São Paulo, SP, Brazil.
Objective:
In the majority of cases, the correct treatment of brain lesions is possible only when the histopathological diagnosis is made. Several deep-seated lesions near eloquent areas are not safely approached by the classical neurosurgical procedures. These patients can get benefit by a minimally invasive procedure.
Method:
We present a series of 176 consecutive patients submitted to stereotactic biopsies due to a great variety of brain lesions.
Results:
Histological diagnosis found in this series: glioma in 40.1% of the patients, other neoplasms in 12.2% and infectious or inflammatory diseases in 29.1 %. The result was inconclusive in 5.2% of the procedures. One patient died (0.6%) and two (1.2%) presented operative complications. The criteria, advantages and risks of the stereotactic biopsies are discussed.
Conclusion:
The efficacy of the method is adequate and morbid-mortality rates were low.
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