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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
Chikungunya infection in children
Meghna R Sebastian1, Rakesh Lodha, S K Kabra
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Insights
Chikungunya fever, a viral illness transmitted by Aedes mosquitoes, presents with varied symptoms. Children are at higher risk for severe disease, requiring careful symptomatic treatment.
Area of Science:
- Virology
- Epidemiology
- Pediatrics
Background:
- Chikungunya virus (CHIK) causes Chikungunya fever, transmitted by Aedes aegypti and Aedes albopictus mosquitoes.
- The disease has a median incubation period of 2 to 4 days and can be transmitted vertically from mother to child.
- Clinical manifestations range from asymptomatic to severe, with children being a high-risk group for severe outcomes.
Purpose of the Study:
- To summarize the clinical manifestations and treatment of Chikungunya fever.
- To highlight the distinct clinical features and risks in pediatric populations.
- To provide guidance on symptomatic management, including medication considerations.
Main Methods:
- Review of clinical manifestations of Chikungunya fever.
- Analysis of risk factors and vulnerable populations, particularly children.
- Summary of current treatment strategies and drug recommendations.
Main Results:
- Common symptoms include fever, rash, arthralgia, and conjunctivitis.
- Severe manifestations and distinct clinical features are observed in children.
- Neurological complications and gastrointestinal symptoms in infants are noted.
- Symptomatic treatment with paracetamol is recommended; NSAIDs are generally avoided but may be used in convalescence.
Conclusions:
- Chikungunya fever presents a broad spectrum of illness, with children facing increased risk of severe disease.
- Prompt recognition of clinical features and appropriate symptomatic management are crucial.
- Further research into pediatric Chikungunya manifestations and optimal treatment is warranted.
Abstract:
Chikungunya fever is caused by Chikungunya virus (CHIK) and spread by Aedes aegypti and Aedes albopictus. The median incubation period is 2 to 4 days. Vertical transmission of disease from mother to child has also been documented. Clinical manifestations are very variable, from asymptomatic illness to severe debilitating disease. Children are among the group at maximum risk for severe manifestations of the disease and some clinical features in this group are distinct from those seen in adults. Common clinical features include: abrupt onset high grade fever, skin rashes, minor hemorrhagic manifestations, arthralgia/ arthritis, lymphadenopathy, conjunctival injection, swelling of eyelids and pharyngitis. Unusual clinical features include: neurological manifestations including seizures, altered level of consciousness, blindness due to retrobulbar neuritis and acute flaccid paralysis. Watery stools may be seen in infants. Treatment is symptomatic. Generally non- steroidal anti-inflammatory drugs are avoided. Paracetamol may be used for pain and fever. However, NSAIDS may be required for relief of severe arthralgia during convalescent phase.
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