Behavioural indexes of callosal functioning in Williams syndrome

Williams syndrome (WS) is a neurogenetic disorder that stems from a microdeletion on chromosome 7. Recent anatomical studies have found evidence for corpus callosum abnormalities in WS. However, to date, the impact of these structural differences on callosal functionality remains unclear. The aim of the present study was to investigate interhemispheric communication and hemispheric asymmetry in individuals with WS relative to mental age-matched controls. This was assessed using bilateral and unilateral presentations of visual stimuli in a picture-naming task. Results found both groups to exhibit a bilateral field advantage and a left visual advantage on unilateral presentations. However, while a significant performance increase with age was found for controls, no such correlation was found for individuals with WS. Taken together, these findings suggest that despite some evidence for an atypical developmental pathway in WS, both interhemispheric communication and hemispheric asymmetry are functionally intact in this population.