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Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels

Chun-Hsiao Chou1, Chi-Li Gong, Chia-Chia Chao

  • 1Department of Physiology, Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung 40402, Taiwan, Republic of China.

Journal of Natural Products
|April 1, 2009
PubMed
Summary

Rhynchophylline, a compound from Uncaria rhynchophylla, accelerates slow inactivation of voltage-gated potassium (Kv) channels. This neuroprotective agent acts extracellularly, altering channel function and potentially impacting neuronal excitability.

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