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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
Published on: April 17, 2020
Rotavirus disease and prevention through vaccination
1Division of Pediatric Infectious Diseases, University of Louisville School of Medicine, Louisville, KY, USA. gsmars01@louisville.edu
The Pediatric Infectious Disease Journal
|April 1, 2009
Summary
Two new rotavirus vaccines are successfully reducing childhood gastroenteritis in the US. This overview covers rotavirus, immunity, vaccine history, and the safety and efficacy of current infant vaccination programs.
Area of Science:
- Pediatric Infectious Diseases
- Vaccinology
- Gastroenterology
Background:
- Rotavirus is a leading cause of severe gastroenteritis in infants globally.
- Significant morbidity and mortality are linked to rotavirus, especially in developing nations.
- The United States has implemented a universal infant vaccination program.
Purpose of the Study:
- To provide an overview of rotavirus structure, pathogenesis, and natural immunity.
- To explain the rationale behind rotavirus vaccine-induced protection.
- To discuss the history, safety, efficacy, and use of approved rotavirus vaccines.
Main Methods:
- Literature review of rotavirus vaccine development.
- Analysis of existing ecologic and post-licensure effectiveness data.
- Synthesis of information on rotavirus immunology and vaccine performance.
Main Results:
- Two oral rotavirus vaccines (RV5 and RV1) are licensed and used in the US.
- Early evidence indicates the infant vaccination program is highly effective.
- The vaccines are associated with reduced rotavirus disease impact.
Conclusions:
- The universal infant rotavirus vaccination program in the US shows unequivocal success.
- Understanding rotavirus natural immunity informs vaccine development and efficacy.
- Current vaccines are safe and effective for preventing rotavirus illness in infants.
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