Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of GABA-immunoreactive neurons in the amygdala after electrical kindling in the rat.

P M Callahan1, J M Paris, K A Cunningham

  • 1Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.

Brain Research
|August 2, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing Cardiac Output Differences in Patients With Fontan Physiology Between High and Low Tidal Volume Strategies: A Randomized, Crossover Trial.

Paediatric anaesthesia·2025
Same author

Covid-19 interface with drug misuse and substance use disorders.

Neuropharmacology·2021
Same author

Ear type in sheep is associated with the MSRB3 locus.

Animal genetics·2020
Same author

A de novo germline mutation of KIT in a white-spotted Brown Swiss cow.

Animal genetics·2020
Same author

Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.

Animal genetics·2019
Same author

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system.

Neuroscience·2016
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

Electrical kindling in rats significantly reduces GABA immunoreactivity in the amygdala, indicating a link between epileptogenesis and decreased GABAergic neurons. This reduction persists for months post-stimulation.

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Neurochemistry

Background:

  • GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the brain.
  • GABAergic dysfunction is implicated in various neurological disorders, including epilepsy.
  • The amygdala plays a crucial role in seizure generation and propagation.

Purpose of the Study:

  • To investigate the long-term effects of electrical kindling on GABA immunoreactivity (GABA-IR) in the rat amygdala.
  • To determine if epileptogenesis in the amygdala leads to persistent changes in GABAergic signaling.

Main Methods:

  • Male Sprague-Dawley rats underwent electrical kindling via bipolar electrodes in the basolateral amygdala.
  • Stimulation continued until 3-5 stage 5 seizures were observed.

Related Experiment Videos

  • Amygdala tissue was analyzed for GABA-IR 2-6 months post-stimulation.

    • Main Results:

    • Fully kindled rats exhibited a significant decrease in the total number of GABA-IR neurons in the lateral and basolateral amygdaloid nuclei compared to controls.
    • A reduction in GABA-positive punctate structures was observed, suggesting altered synaptic GABA levels.
    • These changes were evident in the contralateral amygdala, indicating widespread effects.

    Conclusions:

    • Epileptogenesis in the amygdala is associated with a substantial and lasting reduction in GABA-IR.
    • This suggests that a loss or downregulation of GABAergic neurons contributes to the chronic epileptic state.
    • Findings highlight the role of GABAergic deficits in amygdala-driven epilepsy.