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Response of brain protein kinase C isozymes to ethyl oleate, an alcohol metabolite
1Department of Surgery, College of Medicine, University of Illinois, Chicago 60612.
Brain Research
|August 30, 1991
Abstract:
Rat brain protein kinase C (PKC) isozymes I, II and III were stimulated by fatty acids in the absence and presence of calcium. Ethyl oleate, which by itself has no effect on PKC activity, had a potentiating effect on fatty acid-induced activation of all 3 isozymes. Potentiation was observed predominantly in the presence of calcium. Interaction of ethyl oleate with a signalling mechanism involving PKC may underlie the cognitive disturbances noted after alcohol consumption.