[Disorders of immune response in patients with chronic pancreatitis]

The growth of the number of chronic pancreatitis cases and also the frequency of complications make necessary the in-depth studying of the given disease. However, the questions of the change in local and systemic (general) immunity at patients with chronic pancreatitis remain still not investigated. We examined 70 patients with chronic pancreatitis during exacerbation and remission periods of the disease. The status of local immunity at the level of duodenum was examined as follows: we carried out the immunomorphometric analysis of cells of the proper tunic layer of the mucous membrane of duodenum and the analysis of the level of secretory IgA in duodenal aspirate. In order to examine the humoral immunity we determined the level of immunoglobulin of blood serum. For definition of bacterial overcontamination of small intestine the hydrogen breath test was carried out. The available data of comparative analysis state the decrease in parameters of the local immune response. We revealed the lowering of the level of secretory IgA in duodenal aspirate, the reduction in the number of mast cells, including their degranulated forms, in biopsy material of the mucous membrane of duodenum during the remission period of the chronic pancreatitis. However, no tendency to the change of the level of immunoglobulin in the blood serum was revealed. We can state the overcontamination of small intestine at more than a half of the examined patients.