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Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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Real-time FPGA processing for high-speed optical frequency domain imaging.

Adrien E Desjardins1, Benjamin J Vakoc, Melissa J Suter

  • 1Harvard Biophysics Program, Boston, MA 02115, USA. adrien.desjardins@post.harvard.edu

IEEE Transactions on Medical Imaging
|April 2, 2009
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We developed a new algorithm for optical frequency domain imaging (OFDI) interferogram reconstruction. This method enables real-time processing for high-speed imaging systems using field-programmable gate arrays (FPGAs).

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Area of Science:

  • Optical imaging
  • Signal processing
  • Biomedical engineering

Background:

  • Optical Frequency Domain Imaging (OFDI) is a powerful technique for high-resolution imaging.
  • Interferogram reconstruction is a critical step in OFDI data processing.
  • Real-time processing is essential for high-speed OFDI systems.

Purpose of the Study:

  • To develop a novel algorithm for OFDI interferogram reconstruction.
  • To optimize the algorithm for Field-Programmable Gate Array (FPGA) implementation.
  • To achieve real-time processing of high-speed OFDI data.

Main Methods:

  • Developed a novel reconstruction algorithm for OFDI interferograms.
  • Implemented a Finite-Impulse-Response (FIR) filter for B-spline interpolation.
  • Utilized FPGA for efficient k-space re-sampling and processing.

Main Results:

  • The algorithm enables efficient re-sampling of k-space using FIR B-spline interpolation.
  • FPGA implementation achieved real-time processing of OFDI data.
  • Successfully processed interferograms from a high-speed OFDI system at 54 kHz and 100 MS/s.

Conclusions:

  • The novel algorithm facilitates real-time OFDI interferogram reconstruction.
  • FPGA implementation of the algorithm is suitable for high-speed imaging applications.
  • This advancement improves the efficiency and speed of OFDI data processing.