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Wavenumber-space wavefront sensorless adaptive-optics for optical coherence tomography.

Sebastián Ruiz-Lopera1,2, David Veysset2, Brett E Bouma2,3

  • 1Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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|January 14, 2026
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Summary
This summary is machine-generated.

Adaptive-optics optical coherence tomography (AO-OCT) simplifies retinal imaging by optimizing wavefront correction using k-space fringe modulation. This faster, less complex method enhances cellular-scale visualization for research and clinical applications.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Adaptive-optics optical coherence tomography (AO-OCT) offers cellular-scale retinal visualization.
  • Complexity of current AO-OCT hardware and software limits its research and clinical adoption.

Purpose of the Study:

  • To develop a simplified, faster wavefront correction method for AO-OCT.
  • To improve the accessibility and robustness of AO-OCT for retinal imaging.

Main Methods:

  • Proposed a wavefront sensorless AO-OCT approach using k-space interferometric fringe modulation for optimization.
  • Combined k-space optimization with focal plane shifting (defocus optimization).
  • Evaluated objective function B-scan-wise for 8 Zernike modes correction in ~1.89 seconds.

Main Results:

  • The proposed method demonstrated lower computational complexity and faster optimization per mode compared to depth-resolved optimization.
  • Achieved comparable performance to existing methods using a standard LabVIEW implementation.
  • Successfully demonstrated in vivo human retinal imaging.

Conclusions:

  • The novel k-space optimization approach simplifies AO-OCT, reducing hardware and software requirements.
  • This method enhances AO-OCT robustness and speed, facilitating wider adoption in research and clinics.
  • Enables efficient, high-resolution retinal imaging with potential for improved ophthalmic diagnostics.