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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Updated: Jun 24, 2026

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates
07:23

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

Adipose stem cells and solid organ transplantation.

Sunil S Tholpady1, Roy C Ogle, Adam J Katz

  • 1Department of Plastic and Reconstructive Surgery, University of Virginia, Health Sciences Center, Charlottesville, Virginia, USA.

Current Opinion in Organ Transplantation
|April 2, 2009
PubMed
Summary
This summary is machine-generated.

Adipose stem cells (ASCs) show promise for transplant surgery due to their regenerative capabilities and immune-modulating effects. Research indicates ASCs can differentiate into specific cell types and may treat graft-versus-host disease.

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Last Updated: Jun 24, 2026

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Published on: October 31, 2012

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Transplant Surgery

Background:

  • Adipose stem cells (ASCs) are multipotent stem cells derived from adipose tissue.
  • ASCs possess unique properties relevant to tissue regeneration and immunomodulation.
  • Recent advancements highlight their potential in clinical applications.

Purpose of the Study:

  • To review basic and translational research on adipose stem cells (ASCs).
  • To explore ASC properties beneficial for transplant surgeons, including tissue regeneration, microvasculature support, and immunomodulation.
  • To discuss the expanding future utility of ASCs in transplantation.

Main Methods:

  • Review of recent scientific literature on adipose stem cells.
  • Analysis of research focusing on ASC differentiation, immunomodulatory functions, and clinical case reports.
  • Evaluation of ASC properties relevant to transplant surgery.

Main Results:

  • ASCs demonstrate differentiation potential into hepatic and pancreatic lineages.
  • ASCs exhibit immunomodulatory properties comparable to bone marrow-derived mesenchymal stem cells.
  • Clinical case reports suggest ASCs are effective in treating graft-versus-host disease.

Conclusions:

  • ASCs possess the ability to differentiate into target lineages, enhance angiogenesis, and modulate immune responses.
  • These properties suggest ASCs hold significant clinical utility for transplant surgeons.
  • Further research and application of ASCs are anticipated to expand their role in transplantation.