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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
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Circulating stromelysin concentration is elevated in hypertensive aortic root dilatation.

Irfan Barutcu1, Osman Karakaya, Ali Metin Esen

  • 1Department of Cardiology, Avicenna Hospital, Istanbul, Turkey. irfanbarutcu@yahoo.com

Heart and Vessels
|April 2, 2009
PubMed
Summary

Elevated levels of stromelysin (MMP-3) were found in patients with hypertension-induced aortic root dilatation. This finding suggests MMP-3 may play a role in the development of aortic dilatation in hypertensive individuals.

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Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Medical Diagnostics

Background:

  • Matrix metalloproteinases (MMPs) activity is implicated in aortic dissection and aneurysms.
  • Hypertension is a known risk factor for aortic root dilatation.

Purpose of the Study:

  • To investigate the association between circulating stromelysin (MMP-3) concentration and hypertension-induced aortic root dilatation.
  • To compare MMP-3 levels in hypertensive patients with and without aortic dilatation.

Main Methods:

  • A study population of 42 patients with essential hypertension was divided into two groups based on echocardiographically measured aortic diameter.
  • Plasma MMP-3 concentration was quantified using a one-step sandwich enzyme immunoassay (EIA).

Main Results:

  • Plasma stromelysin (MMP-3) levels were significantly higher in patients with aortic dilatation compared to those without (5.2 +/- 2.3 vs 3.3 +/- 1.9 ng/ml; P = 0.007).
  • Baseline demographic characteristics were similar between the two groups.

Conclusions:

  • Circulating stromelysin (MMP-3) concentration is elevated in hypertension-induced aortic root dilatation.
  • MMP-3 may serve as a potential biomarker for aortic root dilatation in hypertensive patients.