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Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

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Do 'cinnamon-sensitive' patients react to cinnamate UV filters?

Stefanie E Pentinga¹, Dirk J Kuik, Derk P Bruynzeel

¹Department of Dermatology, VU medical Center, Amsterdam, The Netherlands. se.pentinga@vumc.nl

Contact Dermatitis

|April 3, 2009

Summary

Patients sensitive to cinnamon appear to have a low risk of allergic reactions to cinnamate UV filters in sunscreens. However, performing a use test before applying new products is recommended due to potential fragrance allergens.

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Published on: August 25, 2018

Area of Science:

Dermatology
Cosmetic Science
Allergology

Background:

Sunscreens and cosmetic products commonly contain ultraviolet (UV) filters, some of which may act as allergens.
Cinnamate UV filters share structural similarities with cinnamon-derived fragrances, raising concerns for individuals with cinnamon sensitivity.

Purpose of the Study:

To investigate the potential for cinnamate UV filters to cause allergic reactions in patients already sensitized to cinnamon and related fragrances.
To determine if cinnamon-sensitive individuals should avoid cosmetic products containing cinnamate UV filters.

Main Methods:

Photopatch testing was conducted on 18 patients diagnosed with cinnamon sensitivity.
Test materials included cinnamon, cinnamon-related fragrances, Myroxylon pereirae, and two specific cinnamate UV filters.

Main Results:

No positive photopatch test reactions were observed for the tested cinnamate UV filters.
The 95% confidence interval for positive reactions to cinnamate UV filters was 0-13%.

Conclusions:

The risk of allergic contact dermatitis from cinnamate UV filters in cinnamon-sensitive patients appears low, though the study sample size was limited.
Cinnamon-sensitive individuals are advised to conduct a use test (e.g., repeated open application test) before applying new cosmetic products containing cinnamate UV filters.
Healthcare providers and patients should remain aware that sunscreens often contain cinnamon-related fragrances that can independently trigger allergic reactions in sensitive individuals.