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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Toxic Reactions: Overview01:26

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Delayed reactions to reusable protective gloves.

Ann Pontén1, Inese Dubnika

  • 1Department of Occupational and Environmental Dermatology, Lund University, Malmö University Hospital, Malmö, Sweden. ann.ponten@skane.se

Contact Dermatitis
|April 3, 2009
PubMed
Summary
This summary is machine-generated.

Delayed allergic reactions to reusable polyvinyl chloride (PVC) gloves may be as common as those to natural rubber latex (NRL) gloves. This study found similar frequencies of contact allergy to PVC and NRL gloves in dermatitis patients.

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Area of Science:

  • Dermatology
  • Allergology
  • Occupational Health

Background:

  • Plastic protective gloves are often perceived as less allergenic than rubber gloves.
  • Contact allergies to protective gloves are a concern in occupational health and dermatology.
  • Natural rubber latex (NRL) gloves are a known cause of allergic contact dermatitis.

Purpose of the Study:

  • To determine the frequency of delayed allergic reactions to different types of reusable protective gloves.
  • To compare the allergenic potential of polyvinyl chloride (PVC), nitrile, and NRL gloves.
  • To investigate associations between glove allergies and baseline patch test results.

Main Methods:

  • Consecutive dermatitis patients underwent patch testing with glove materials.
  • Standardized 2x2 cm glove pieces (PVC, nitrile, NRL) were applied directly.
  • Patients were assessed for delayed hypersensitivity reactions.

Main Results:

  • Out of 658 patients, 6 reacted to PVC gloves and 6 reacted to NRL gloves.
  • No patients showed reactions to both PVC and NRL gloves.
  • Five of the six patients reacting to NRL gloves also reacted to thiuram mix in baseline series.

Conclusions:

  • Delayed reactions to reusable PVC gloves may be as frequent as to reusable NRL gloves.
  • Unlike NRL glove reactions, PVC glove reactions showed no clear association with baseline allergens.
  • Nitrile gloves did not elicit any reactions in this patient cohort.