First evidence of association between G72 and bipolar disorder in the Chinese Han population
Zhao Zhang1, You Li, Qian Zhao
1Changing Institute of Mental Health, Institute of Neuropsychiatric Science and Systems Biological Medicine, Xiehe Road 299, Bio-X Center Hospital, Bio-X Center, Shanghai Jiao Tong University, Shanghai, PR China.
Abstract:
The G72/G30 (D-amino-acid oxidase activator) complex was the first gene to be associated with bipolar disorder (BPD) in European populations, but until now no such association has been identified in Asian populations. To investigate possible association in the Chinese Han population, we carried out a study involving 475 BPD patients and 588 healthy controls. The results provide first evidence for the single nucleotide polymorphism rs778293 in G72 as a potential candidate in altering risk for BPD in the Chinese Han population.
Related Concept Videos
Bipolar Disorder
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Psychological and Sociocultural Causes of Schizophrenia
Single Nucleotide Polymorphisms-SNPs
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Bulimia Nervosa
