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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
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Published on: January 19, 2024

Melasma: treatment evaluation.

Ahmed Salem1, Hend Gamil, Ali Ramadan

  • 1Department of Dermatology and Venereology, Faculty of Medicine, Zagazig University, Egypt. aasalem@live.com

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
|April 3, 2009
PubMed
Summary

Topical hydroquinone cream is the most effective treatment for melasma in Egyptian patients with skin types IV-V. This treatment showed superior results compared to chemical peels or laser therapy for facial hyperpigmentation.

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Area of Science:

  • Dermatology
  • Cosmetic Science

Background:

  • Melasma is a prevalent facial hyperpigmentation disorder.
  • It often presents resistance to conventional treatments.
  • Egyptian patients typically have skin types IV-V, common in sunny climates.

Purpose of the Study:

  • To assess the clinical effectiveness of various melasma treatment modalities.
  • To compare topical hydroquinone, chemical peels, and laser therapy.
  • To evaluate treatments in Egyptian patients with skin types IV-V.

Main Methods:

  • 45 patients with moderate-to-severe melasma were included.
  • Treatments involved hydroquinone 4% cream, 30% trichloroacetic acid (TCA) peels, and/or Q-switched Nd:YAG laser.
  • Treatment duration averaged 6 months, with evaluation using the Melasma Area and Severity Index (MASI) score.

Main Results:

  • Topical hydroquinone demonstrated significantly higher improvement scores (p<0.0001).
  • No significant difference in efficacy was observed between laser and peeling treatments.
  • Epidermal melasma showed greater improvement than dermal melasma (p<0.01).

Conclusions:

  • Topical hydroquinone 4% cream is the most effective treatment for melasma in darker skin types.
  • This treatment offers a favorable profile with rare side effects.
  • Hydroquinone remains a primary therapeutic option for melasma in this population.