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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

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[Is lymphoma curable with antibody therapy?]

Sirpa Leppä1, Heidi Nyman, Marja-Liisa Karjalainen-Lindsberg

  • 1HUS, Syöpätautien klinikka, PL 180, 00029 HUS.

Duodecim; Laaketieteellinen Aikakauskirja
|April 4, 2009
PubMed

Diagnostics of non-Hodgkin's lymphomas has improved significantly over the last decades. Predictors have been found and new biological therapies developed. Rituximab, an antibody recognizing the CD20 B cell antigen, has proven to be of especially high clinical importance. In a proportion of follicular lymphomas, long responses are achieved with rituximab alone, without the adverse effects of cytotoxic agents. On the other hand, combining rituximab with cytotoxic agents extends the non-diseased period and total survival period both in follicular and diffuse large B cell lymphoma.

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