Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated analytical characterization and multiscale modeling of supramolecular interactions in lumefantrine-curcumin coamorphous systems with enhanced biopharmaceutical and anticancer performance.

Talanta·2026
Same author

Development, validation and application of LC-MS/MS method for simultaneous determination of irinotecan and cyclosporine in co-loaded self-nanoemulsifying drug delivery system.

Annales pharmaceutiques francaises·2026
Same author

Mechanistic enhancement of oral bioavailability through a coamorphous apremilast-aceclofenac systems: integrated LC-MS/MS Bioanalysis, in vivo pharmacokinetics, and PBPK modeling.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Uveitis Management at the Crossroads of Pharmacotherapy, Nanotechnology, and Intellectual Property.

ACS applied bio materials·2026
Same author

In Vitro and In Vivo Assessment of Darolutamide Encapsulated Lipid-Extruded PEGylated Liposomal Formulation.

ACS applied bio materials·2026
Same author

Addressing delivery and resistance issues of CDK4/6 inhibitors as cancer therapeutics.

Drug discovery today·2026

Related Experiment Video

Updated: Jun 24, 2026

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Carbohydrate-conjugated multiwalled carbon nanotubes: development and characterization.

Amit K Jain1, Vaibhav Dubey, Neelesh Kumar Mehra

  • 1Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India. jnarendr@yahoo.co.in

Nanomedicine : Nanotechnology, Biology, and Medicine
|April 4, 2009
PubMed
Summary

Researchers developed galactosylated multiwalled carbon nanotubes (MWCNTs) by chemically modifying them with D-galactose. This process enhances MWCNT dispersibility in water, enabling targeted delivery to hepatic tissues.

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves
09:35

Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves

Published on: April 10, 2015

Related Experiment Videos

Last Updated: Jun 24, 2026

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves
09:35

Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves

Published on: April 10, 2015

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Multiwalled carbon nanotubes (MWCNTs) possess unique properties but often exhibit poor dispersibility in aqueous media.
  • Chemical functionalization is crucial for tailoring MWCNT properties for specific applications.
  • Carbohydrate conjugation offers a pathway to improve biocompatibility and targeting capabilities.

Purpose of the Study:

  • To develop a novel cascade functionalization of MWCNTs using D-galactose.
  • To investigate the impact of galactosylation on MWCNT properties, particularly dispersibility.
  • To explore the potential of galactosylated MWCNTs for targeted delivery applications.

Main Methods:

  • Sequential chemical modification of MWCNTs including carboxylation, acylation, amine modification, and galactose conjugation.
  • Characterization of functionalized MWCNTs using elemental analysis, XRD, FTIR, Raman spectroscopy, and zeta potential measurements.
  • Assessment of MWCNT size, surface characteristics, and dispersion properties using electron microscopy and pH-dependent dispersion studies.

Main Results:

  • Successful synthesis of galactose-conjugated (galactosylated) MWCNTs through a multi-step chemical process.
  • Comprehensive characterization confirmed successful functionalization at each step.
  • Galactosylation significantly improved the dispersibility of MWCNTs in aqueous solvents across various pH values.

Conclusions:

  • The developed galactosylated MWCNTs exhibit enhanced dispersibility, overcoming a key limitation of pristine MWCNTs.
  • The galactose ligand provides a basis for active ligand-based targeting, specifically to hepatic tissues.
  • These galactosylated MWCNTs hold promise for the targeted delivery of bioactive agents to the liver.