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Related Experiment Video

Updated: Jun 24, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Why an alternative to blood transfusion?

Aryeh Shander¹, Lawrence Tim Goodnough

¹Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Englewood Hospital and Medical Center, Englewood, NJ 07631, USA. aryeh.shander@ehmc.com

Critical Care Clinics

|April 4, 2009

Summary

This summary is machine-generated.

Allogeneic blood transfusions pose risks and face shortages. Exploring alternatives to allogeneic blood is crucial for improving patient outcomes and addressing supply challenges.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Published on: June 14, 2024

Area of Science:

Transfusion Medicine
Patient Safety
Healthcare Logistics

Background:

Allogeneic blood transfusions are linked to significant risks and poorer patient outcomes across various clinical settings.
The procurement, transportation, and storage of allogeneic blood present considerable logistical challenges and costs.
Imminent global and local shortages of allogeneic blood necessitate the exploration of alternative strategies.

Purpose of the Study:

To highlight the risks and complications associated with allogeneic blood transfusions.
To underscore the logistical and economic difficulties in managing allogeneic blood supply.
To advocate for the development and adoption of alternatives to allogeneic blood transfusions.

Main Methods:

Literature review on transfusion risks and complications.
Analysis of supply chain challenges for blood products.
Examination of emerging transfusion alternatives.

Main Results:

Allogeneic transfusions are associated with adverse events and suboptimal patient outcomes.
Blood banking faces increasing strain due to cost and supply chain vulnerabilities.
Alternative transfusion strategies offer potential benefits over traditional methods.

Conclusions:

Reducing reliance on allogeneic blood transfusions is essential for patient safety.
Developing and implementing transfusion alternatives can mitigate risks and improve care.
Innovation in transfusion medicine is critical to address current and future blood supply challenges.