Hemoglobin-based oxygen carriers: first, second or third generation? Human or bovine? Where are we now?
1Department of Surgery, University of Michigan, Acute Care Surgery 1C340A-UH, Ann Arbor, MI 48109-5033, USA. lenan@umich.edu
Critical Care Clinics
|April 4, 2009
Summary
Developing hemoglobin-based oxygen carriers addresses the global blood shortage. Polymerized hemoglobin shows promise as a safe blood substitute with improved efficacy and fewer side effects compared to traditional transfusions.
Area of Science:
- Biomedical Engineering
- Hematology
- Transfusion Medicine
Background:
- Global shortage of safe allogeneic donor blood necessitates alternatives.
- Hemoglobin-based oxygen carriers (HBOCs) are being developed as blood substitutes.
- Current allogeneic blood transfusion safety concerns drive research.
Purpose of the Study:
- To discuss current efforts in developing HBOCs.
- To evaluate HBOCs with enhanced intravascular retention and reduced adverse effects.
- To compare HBOCs against allogeneic blood transfusions.
Main Methods:
- Modification of hemoglobin's intrinsic biologic properties.
- Development of polymerized hemoglobin preparations.
- Clinical trials evaluating safety and efficacy.
Main Results:
- Polymerized hemoglobin preparations demonstrate success in clinical trials.
- Improved side effect profiles observed with polymerized hemoglobin.
- HBOCs aim for enhanced intravascular retention and reduced osmotic activity.
Conclusions:
- HBOCs, particularly polymerized hemoglobin, offer a viable alternative to allogeneic blood.
- Further comparative studies are needed to demonstrate minimal adverse effects and efficacy.
- HBOCs hold potential for novel applications in transfusion medicine.
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