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Myasthenia gravis seven years after removal of an invasive thymoma
Andrew W Barritt1, Ann M Bacsi, Mark Tschuchnigg
1Medical Eye Unit, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, United Kingdom. awb@doctors.org.uk
Abstract:
This report describes a 59-year-old male who developed myasthenia gravis 92 months following excision of an invasive thymoma, in the absence of tumour recurrence. This report highlights the importance of prolonged clinical surveillance in post-thymectomy patients.
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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
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01:28Disorders of the Skeletal Muscle
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