Related Experiment Video

Updated: Jun 24, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

Association between mean arterial pressure and mortality in chronic hemodialysis patients

Shu-Ming Wang1, Shi-Yann Cheng, Che-Yi Chou

  • 1Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Kidney & Blood Pressure Research
|April 4, 2009
PubMed

Insights

Low predialytic mean arterial pressure (MAP) and rising MAP during hemodialysis (HD) are linked to higher mortality in chronic HD patients. Further research is needed to optimize treatment for these individuals.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Epidemiology

Background:

  • Low mean arterial pressure (MAP) is linked to poor outcomes in cardiovascular disease.
  • The prognostic significance of MAP in chronic hemodialysis (HD) patients remains unclear.

Purpose of the Study:

  • To investigate the association between MAP and mortality in chronic HD patients.
  • To determine if predialytic MAP or MAP changes during HD influence patient survival.

Main Methods:

  • Prospective analysis of chronic HD patients from February 2001 to February 2006.
  • Kaplan-Meier analysis and Cox regression were used to assess mortality risk.
  • Adjustments were made for age, gender, and diabetes.

Main Results:

  • A total of 834 patients were analyzed over an average of 36.3 months, with 205 (24.6%) deaths.
  • Lower predialytic MAP (<90 mm Hg) was associated with increased mortality (p=0.044).
  • An increase in MAP during HD sessions was also significantly associated with higher mortality risk (p=0.002).

Conclusions:

  • Lower predialytic MAP and MAP increase during HD are associated with increased mortality in Asian HD patients.
  • Optimal management strategies for hypertensive HD patients require further investigation through interventional studies.
Abstract

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...