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Managing potentially resectable metastatic colon cancer
1Division of Hematology and Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC.
Gastrointestinal Cancer Research : GCR
|April 4, 2009
Summary
Management for metastatic colon cancer has advanced to include resecting multiple metastases and using combination chemotherapy. This progress raises new questions about adjuvant chemotherapy timing, agents, and its role in downstaging tumors.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- Management for metastatic colon cancer has evolved significantly.
- Current approaches involve resection of multiple metastases and combination chemotherapy.
Purpose of the Study:
- To discuss key issues in the evolving management paradigm for resectable colorectal cancer metastases.
- To address emerging questions regarding adjuvant chemotherapy protocols.
Main Methods:
- Review of recent clinical trials and management strategies.
- Discussion of current controversies and future directions in treatment.
Main Results:
- Advancements in surgical resection and combination chemotherapy have improved outcomes.
- New treatment paradigms raise complex questions regarding adjuvant therapy.
Conclusions:
- The management of resectable colorectal cancer metastases is increasingly complex.
- Further research is needed to optimize adjuvant chemotherapy strategies and timing.