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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

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Related Experiment Video

Updated: May 10, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Surgical adjuvant chemotherapy.

M Perloff, J F Holland

    Annual Review of Medicine
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Surgical adjuvant chemotherapy, proven effective in animal models, now offers cures for several human neoplastic diseases. This approach significantly improves outcomes for previously fatal childhood cancers and Stage II breast cancer.

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    Area of Science:

    • Oncology
    • Surgical Oncology
    • Medical Oncology

    Background:

    • Principles of surgical adjuvant chemotherapy, initially developed in experimental animal systems, have demonstrated applicability to human neoplastic diseases.
    • Effective chemotherapy can eradicate micrometastatic disease, a crucial step in improving patient outcomes.

    Purpose of the Study:

    • To present evidence demonstrating the efficacy of surgical adjuvant chemotherapy in treating various human cancers.
    • To highlight the potential of chemotherapy to prolong disease-free intervals and achieve cures where traditional methods fall short.

    Main Methods:

    • Review and synthesis of evidence from experimental animal systems and clinical applications of surgical adjuvant chemotherapy.
    • Analysis of treatment outcomes for specific cancers including Wilms' tumor, Ewings' sarcoma, embryonal rhabdomyosarcoma, osteogenic sarcoma, and Stage II breast cancer.

    Main Results:

    • Surgical adjuvant chemotherapy has led to cures in previously fatal childhood solid tumors and significant improvements in Stage II breast cancer treatment.
    • This approach prolongs disease-free intervals in osteogenic sarcoma, enabling novel surgical strategies beyond traditional amputation.
    • Clinically evident metastatic disease remains challenging, but adjuvant chemotherapy shows promise in extending survival.

    Conclusions:

    • Surgical adjuvant chemotherapy, in combination with surgery, radiotherapy, and immunotherapy, offers a more efficacious treatment paradigm than single-modality approaches.
    • The evidence strongly supports the potential for cure in a variety of neoplastic diseases through the strategic application of chemotherapy.
    • Improved drug delivery, favorable cellular kinetics, and a robust host immune response contribute to the success of adjuvant chemotherapy.