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Updated: Jun 24, 2026

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
Published on: May 13, 2015
An infant with self-healing cutaneous Langerhans cell histiocytosis followed by isolated thymic relapse
Naoki Hatakeyama1, Tsukasa Hori, Masaki Yamamoto
1Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. nhatake@sapmed.ac.jp
Abstract:
Thymic involvement with Langerhans cell histiocytosis (LCH) typically occurs in children as part of multi-system (M-S) LCH. Patients who develop skin-only LCH during infancy may either follow a self-healing course with spontaneous regression or may progress to M-S involvement. We describe a male infant who developed isolated thymic LCH after spontaneous complete regression of isolated cutaneous lesions. His erythrocyte sedimentation rate and C-reactive protein increased temporarily during the skin-only stage of LCH, and increased again considerably during the thymic relapse. Even for patients with skin-only LCH, these laboratory data might indicate possible relapse or late progression of the disease.
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