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Related Experiment Video

Updated: Jun 24, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

HIV-associated multicentric Castleman disease.

Eric Oksenhendler¹

¹Department of Clinical Immunology, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France. eric.oksenhendler@sls.aphp.fr

Current Opinion in HIV and AIDS

|April 7, 2009

Summary

Etoposide is the most effective first-line therapy for HIV-associated multicentric Castleman disease. Rituximab offers high remission rates, while valganciclovir helps suppress human herpesvirus 8 (HHV-8) replication.

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Last Updated: Jun 24, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Area of Science:

Hematology
Infectious Diseases
Oncology

Background:

HIV-associated multicentric Castleman disease (MCD) is a complex lymphoproliferative disorder.
Pathophysiology involves human herpesvirus 8 (HHV-8) infected plasmablasts and viral replication.

Purpose of the Study:

Review recent findings in HIV-associated MCD.
Illustrate therapeutic approaches based on current pathophysiology.
Provide guidelines for initial disease management.

Main Methods:

Review of pathological and virological data.
Analysis of therapeutic strategies targeting infected cells and viral replication.

Main Results:

Etoposide demonstrates efficacy as a first-line therapy for active MCD.
Rituximab achieves over 70% 1-year remission rates when used post-initial control.
Valganciclovir suppresses HHV-8 replication, with suggested clinical improvement.

Conclusions:

Etoposide is recommended as the primary treatment for active HIV-associated MCD.
Rituximab is a viable option for maintaining remission.
Valganciclovir shows promise in managing HHV-8 viremia, though Kaposi sarcoma exacerbation is a consideration.