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Updated: Jun 24, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Feminizing adrenocortical adenoma in a 5 year-old girl
Olfa Bouyahia1, Lamia Gharsallah, Monia Ouederni
1Paediatric Department C, Children's Hospital of Tunis, Tunisia. olfa.bouyahia@rns.tn
Abstract:
Adrenocortical adenoma is a rare etiology of isosexual precocious puberty in girls. We report the case of a 5 year-old girl with isosexual precocious puberty. Abdominal ultrasound and magnetic resonance imaging revealed a well-defined mass of 32 x 28 mm situated in the left suprarenal region, but no signs of calcification or metastasis. Estradiol and testosterone levels were elevated, cortisol plasma level was normal, and bolus intravenous injection of GnRH showed unresponsiveness of LH and FSH. Pathological examination after complete surgical resection showed an adrenocortical adenoma. Five years later, there had been no recurrence and abdominal ultrasound examination was normal. The diagnosis of feminizing adrenocortical adenoma was confirmed.
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