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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Related Experiment Video

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Alkaloids as potential anti-tubercular agents.

Navneet Kishore1, Bhuwan B Mishra, Vyasji Tripathi

  • 1Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221005, India.

Fitoterapia
|April 7, 2009
PubMed
Summary

Tuberculosis deaths are rising, driving the search for new drugs. Natural alkaloids show promise as effective anti-tubercular agents with novel mechanisms against resistant strains.

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Microbiology

Background:

  • Rising tuberculosis (TB) mortality and drug resistance necessitate novel therapeutic strategies.
  • Current anti-TB drugs have limitations, including toxicity and the emergence of multi-drug resistant (MDR-TB) strains.
  • Natural products, particularly alkaloids, offer a promising avenue for discovering new anti-TB drug candidates.

Purpose of the Study:

  • To review the current landscape of tuberculosis, including its epidemiology and co-infection with HIV.
  • To examine existing anti-TB therapies and identify molecular targets for drug development.
  • To highlight the significance of natural products, especially alkaloids, in the search for new anti-tubercular agents.

Main Methods:

  • Literature review focusing on alkaloids with antimycobacterial activity from mid-1980s to late 2008.
  • Analysis of structure-activity relationships (SAR) for identified alkaloids.
  • Synthesis of information on TB epidemiology, HIV co-infection, and current treatment challenges.

Main Results:

  • Alkaloids have demonstrated significant activity against Mycobacterium tuberculosis.
  • Structure-activity relationship studies provide insights into the chemical features crucial for antimycobacterial efficacy.
  • Natural products represent a valuable resource for developing novel anti-TB drugs.

Conclusions:

  • Natural product-derived alkaloids are vital in the ongoing quest for new anti-tuberculosis treatments.
  • Further research into alkaloid SAR can guide the development of more potent and effective anti-TB agents.
  • Addressing the challenges of drug resistance and TB mortality requires exploring innovative therapeutic sources like natural alkaloids.