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Related Experiment Video

Updated: Jun 24, 2026

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

Published on: August 28, 2019

Gabapentin responsive audiovestibular paroxysmia.

Douglas Russell¹, Robert W Baloh

¹Jefferson Medical College, 1020 Walnut Street, Philadelphia, PA 19107-5587, USA. douglas.russell@jefferson.edu

Journal of the Neurological Sciences

|April 7, 2009

Summary

Vascular compression of the 8th cranial nerve may cause tinnitus and vertigo. Low-dose gabapentin effectively treated two patients, suggesting a new syndrome: 8th nerve vascular compression.

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Area of Science:

Neurology
Neuroscience
Otolaryngology

Background:

Trigeminal neuralgia (5th cranial nerve) and hemifacial spasm (7th cranial nerve) are established vascular compression syndromes.
Current treatments include nerve-stabilizing drugs and vascular decompression surgery.

Observation:

Two patients presented with recurrent, spontaneous episodes of tinnitus and vertigo.
These symptoms are characteristic of potential 8th cranial nerve dysfunction.

Findings:

The patients' symptoms significantly improved with low-dose gabapentin treatment.
This response suggests gabapentin's efficacy in managing 8th nerve-related symptoms.

Implications:

This study proposes a distinct clinical syndrome: 8th nerve vascular compression.
The findings may lead to new diagnostic and therapeutic approaches for vertigo and tinnitus.
Further research is warranted to validate this syndrome and its treatment.