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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
Exploring the relationship between physiological measures of cochlear and brainstem function.
1Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA. s-dhar@northwestern.edu
Summary
Objective measures of hearing, distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs), show significant relationships between cochlear function and brainstem responses in normal-hearing adults.
Area of Science:
- Auditory Neuroscience
- Audiology
- Otoacoustic Emissions
Background:
- Otoacoustic emissions (OAEs) and speech-evoked auditory brainstem responses (sABRs) are objective measures of peripheral auditory function.
- While individually well-studied, the relationship between OAEs and sABRs is not well understood.
Purpose of the Study:
- To investigate the interdependence between distortion product otoacoustic emissions (DPOAEs) and speech-evoked auditory brainstem responses (sABRs) in normal-hearing adults.
- To explore correlations between DPOAE characteristics and sABR timing and frequency encoding.
Main Methods:
- Recorded DPOAEs and sABRs from 28 normal-hearing adults.
- Correlated DPOAE Strength and Structure with five sABR measures (Onset, Spectrotemporal, Harmonics, Envelope Boundary, Pitch).
Main Results:
- DPOAE Strength correlated significantly with sABR Spectrotemporal and Harmonics measures.
- DPOAE Structure correlated significantly with sABR Envelope Boundary.
- No significant relationship was found between DPOAEs and sABR Pitch.
Conclusions:
- Specific aspects of sABRs covary with cochlear function measured by DPOAEs.
- Findings support parallel analysis of cochlear and brainstem function for improved clinical assessment of hearing and language disorders.
