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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Capillary Beds01:20

Capillary Beds

Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...

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Related Experiment Video

Updated: Jun 24, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

The microcirculation as a clinical concept: work in progress.

E Christiaan Boerma1

  • 1Department of Translational Physiology, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands. e.boerma@chello.nl

Current Opinion in Critical Care
|April 7, 2009
PubMed
Summary
This summary is machine-generated.

Direct in-vivo observation has transformed the understanding of microcirculation, revealing its critical role in disease. This advancement aids in developing strategies to improve patient outcomes in critical care settings.

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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Related Experiment Videos

Last Updated: Jun 24, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

  • Physiology
  • Critical Care Medicine
  • Medical Imaging

Background:

  • Microcirculation was a theoretical concept.
  • Direct in-vivo observation techniques revolutionized its study.

Purpose of the Study:

  • To review the evolution of microcirculation from theory to clinical concept.
  • To highlight advancements in in-vivo observation techniques.

Main Methods:

  • Review of technical proceedings in microcirculatory imaging.
  • Analysis of experimental data on leukocyte dynamics, vascular permeability, and hypoxia.
  • Inclusion of in-vivo mitochondrial pO2 measurements.

Main Results:

  • Demonstrated heterogeneity of microcirculatory blood flow.
  • Expanded prognostic value of microcirculatory alterations to sepsis and postoperative patients.
  • Discussed interventions influencing microcirculatory changes in shock.

Conclusions:

  • Microcirculatory failure is now a clinical concept in critically ill patients.
  • Future challenges include developing strategies to improve microcirculation and patient outcomes.