The diversity and unity of Herpesviridae

The family herpesviridae contains over 100 viruses endogenous to humans and to a wide variety of eukaryotic organisms. Inclusion in the family is based on architecture of the virion. The viruses differ significantly with respect to base composition and sequence arrangements of their DNAs, but share many biologic properties including the ability to remain latent in their hosts. On the basis of their biologic properties the herpesviruses have been classified into three subfamilies, i.e. alphaherpesvirinae, betaherpesvirinae and gammaherpesvirinae. The members of each subfamily share many properties including greater conservation and colinear arrangements of their genes. As a rule, more than one herpesvirus has been isolated from animals of economic importance and both humans have yielded viruses belong to all three subfamilies of the herpesviridae.