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Updated: Jun 24, 2026
11:26
Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
Published on: August 14, 2014
Endothelial adapter proteins in leukocyte transmigration.
Jaap D van Buul1, Peter L Hordijk
1Dept. Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Thrombosis and Haemostasis
|April 8, 2009
Summary
Adapter proteins are crucial for leukocyte transendothelial migration (TEM). They link adhesion molecules to the cytoskeleton and signaling pathways, enabling endothelial cells to facilitate immune cell movement.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Background:
- Leukocyte transendothelial migration (TEM) is a critical immune process.
- Endothelial signaling initiates and regulates TEM.
- Adapter proteins link cell-surface adhesion molecules to intracellular pathways.
Purpose of the Study:
- To define common themes in adapter protein binding within endothelial cells.
- To propose critical functions of adapter proteins in leukocyte TEM.
- To review the role of adapter proteins in immune cell trafficking.
Main Methods:
- Literature review of studies on leukocyte TEM and endothelial cell signaling.
- Analysis of adapter protein interactions with adhesion molecules.
- Examination of downstream signaling pathways involving adapter proteins like cortactin and filamin.
Main Results:
- Adapter proteins form a bridge between adhesion molecules and the actin cytoskeleton.
- These proteins are essential for transmitting signals initiated at the cell surface.
- Specific adapter proteins, including cortactin and filamin, play key roles in regulating endothelial cell responses during TEM.
Conclusions:
- Adapter proteins are central regulators of endothelial signaling during leukocyte TEM.
- Understanding adapter protein functions provides insights into immune cell trafficking and inflammatory responses.
- Targeting adapter protein interactions may offer therapeutic strategies for inflammatory diseases.
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