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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
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[Renal compromise in HIV/AIDS in patients attended at a Chilean children hospital]

Pedro Zambrano O1, Ana Chávez P, Ximena Chaparro R

  • 1Unidad de Nefrología, Hospital de Niños Dr. Exequiel González Cortés, Santiago, Chile. phzambrano@hotmail.com

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|April 8, 2009
PubMed

Insights

Nearly 40% of HIV-positive children in a Chilean hospital study had renal abnormalities, highlighting the need for widespread screening for pediatric kidney disease in this population.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Public Health

Context:

  • Human Immunodeficiency Virus (HIV) infection can affect multiple organ systems, including the kidneys.
  • Pediatric HIV patients are at risk for developing renal complications.
  • Limited data exists on the prevalence of renal abnormalities in HIV-positive children in Chile.

Purpose:

  • To determine the frequency of renal abnormalities in HIV-positive children treated at a pediatric hospital in Chile.

Summary:

  • A cross-sectional study evaluated 18 HIV-positive children (vertical transmission) aged 4-19 years.
  • Renal abnormalities detected included microalbuminuria, hematuria, squamous cells in urine, hypercalciuria, renal lithiasis, and abnormal renal ultrasonography.
  • Overall, 39% of the patients exhibited at least one renal abnormality, despite normal blood pressure.

Impact:

  • Findings suggest a significant burden of renal disease in pediatric HIV patients in Chile.
  • Supports the necessity of implementing a national screening program for renal impairment in this vulnerable group.
  • Emphasizes the importance of early detection and management of kidney complications in children living with HIV.
Abstract

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