Papules arising after radiotherapy for rhabdomyosarcoma

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Radiation therapy, even at low doses, can induce diverse vascular skin proliferations.
• These can range from benign lymphangiomatous papules (BLAP) to malignant angiosarcoma.

Observation:

• A 50-year-old woman, previously treated for uterine rhabdomyosarcoma with radiotherapy, presented with skin-colored papules in the irradiated area.
• Histopathology revealed irregular vascular channels lined by prominent endothelial cells, without atypia or mitotic activity.

Findings:

• Immunohistochemistry confirmed endothelial cell markers D2-40 and CD31.
• The diagnosis was benign lymphangiomatous papules (BLAP) secondary to prior radiotherapy.

Implications:

• This case underscores BLAP as a potential benign sequela of radiotherapy.
• Early diagnosis and complete excision are crucial for managing these radiation-induced vascular lesions.