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Updated: Jun 24, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Advances in the studies of the dysbindin gene in schizophrenia]
Gao-feng Zhao1, Hong Deng, Yan-chun Yang
1West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Abstract:
Recent reports indicate that the dysbindin gene located on chromosome 6p22.3 is a major susceptibility gene for schizophrenia. In the brain, the dysbindin gene may influence glutamatergic neurotransmission by multiple post- and pr- synaptic mechanisms. This paper reviews the research progress on the dysbindin gene in schizophrenia, including the dysbindin gene and its product, the possible pathogenic mechanisms, the association study of the dysbindin gene with schizophrenia, and the cognitive decline caused by the dysbind in variations.
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