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Related Experiment Video

Updated: Jun 24, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Recent advances in Clostridium difficile-associated disease.

T Monaghan¹, T Boswell, Y R Mahida

¹Institute of Infection, Immunity & Inflammation, University of Nottingham and Nottingham University Hospitals NHS Trust, UK.

Postgraduate Medical Journal

|April 9, 2009

Summary

This review covers new treatments for Clostridium difficile-associated disease (CDAD), including antibiotics and non-antibiotic options. It also discusses infection control and the management of severe CDAD cases.

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

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Published on: May 25, 2017

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Last Updated: Jun 24, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

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Published on: December 10, 2016

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

Infectious Diseases
Microbiology
Gastroenterology

Background:

Clostridium difficile-associated disease (CDAD) presents challenges in management due to recurrent infections and emerging strains.
Current treatment strategies involve antibiotics, but novel approaches are needed to address resistance and recurrence.

Purpose of the Study:

To review recent advancements in managing acute and recurrent Clostridium difficile-associated disease.
To evaluate existing and emerging antibiotic and non-antibiotic therapeutic agents.
To discuss infection control strategies and the role of surgery in severe cases.

Main Methods:

Literature review of recent developments in Clostridium difficile-associated disease management.
Analysis of current and investigational treatments, including antibiotic and non-antibiotic agents.
Discussion of pathogenesis, clinical presentation, diagnosis, and infection control measures.

Main Results:

Several new antibiotic and non-antibiotic agents are in development for CDAD treatment.
Prudent antimicrobial use, cross-infection prevention, and surveillance are key infection control measures.
Surgery remains an option for severe, refractory CDAD cases.

Conclusions:

The management of Clostridium difficile-associated disease is evolving with new therapeutic options.
A multi-faceted approach combining novel treatments, infection control, and judicious use of surgery is crucial.
Understanding pathogenesis and rapid diagnosis are vital for effective patient care.