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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Localized surface plasmon resonance biosensor integrated with microfluidic chip.

Chengjun Huang¹, Kristien Bonroy, Gunter Reekmans

¹Interuniversity Microelectronics Center (IMEC), Kapeldreef 75, B-3001 Leuven, Belgium. chengjun.huang@yahoo.com

Biomedical Microdevices

|April 9, 2009

Summary

This summary is machine-generated.

A novel microfluidic biosensor uses gold nanoparticles and localized surface plasmon resonance (LSPR) for sensitive, label-free detection of biomolecular interactions. This low-cost, integrated system offers a portable alternative to conventional biosensors.

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Last Updated: Jun 24, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

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Published on: March 17, 2023

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

Nanotechnology
Biosensing
Microfluidics

Background:

Localized surface plasmon resonance (LSPR) biosensors offer label-free detection of biomolecular interactions.
Conventional LSPR biosensors can be expensive and lack portability.
Microfluidic integration offers potential for miniaturization and cost reduction.

Purpose of the Study:

To develop a sensitive, low-cost, and portable microfluidic biosensor.
To enable real-time, label-free monitoring of biomolecular interactions.
To demonstrate the feasibility of integrating LSPR with microfluidic technology.

Main Methods:

Utilized gold nanoparticles for LSPR properties.
Implemented a novel quadrant detection scheme with a green light-emitting diode (LED).
Integrated the biosensor onto a microfluidic chip for sample handling.

Main Results:

Achieved a refractive index unit (RIU) resolution of 10⁻⁴, comparable to conventional LSPR biosensors.
Demonstrated label-free detection of an antigen/antibody (biotin/anti-biotin) system.
Attained a detection limit of 270 ng/mL for anti-biotin with reduced reaction time and reagent consumption.

Conclusions:

The developed microfluidic integrated biosensor is a sensitive and low-cost platform.
Integration of LSPR and microfluidics offers a portable biosensing solution.
The system provides a viable, cost-effective alternative to commercial surface plasmon resonance (SPR) instruments.