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Updated: Jun 24, 2026
Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
Cytology and flow cytometry to identify ectopic thymic tissue masquerading as a thyroid nodule in two children
Lourdes Aguayo-Figueroa1, Marc G Golightly, Youjun Hu
1Division of Pediatric Endocrinology, Department of Pediatrics, State University of New York, Stony Brook, New York 11794-8111, USA.
Background:
Clinically unapparent thyroid nodules in children pose a significant problem in differential diagnosis and management. Ectopic thymic tissue in the thyroid gland is rare, but may masquerade as a thyroid nodule. This paper demonstrates the utility of flow cytometry as an adjunct to cytology by fine needle aspiration in diagnosing ectopic thymic tissue in the thyroid gland.
Summary:
By demonstration of T lymphocytes maturing along two cell lineages and the absence of markers for malignant lesions, fine-needle aspiration, cytology, and flow cytometry were used to identify ectopic thymic tissue masquerading as a thyroid nodule in two children.
Conclusion:
Use of this technique prevented surgical intervention that otherwise would have been necessary to obtain an accurate diagnosis of these thyroid nodules.
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