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Updated: Jun 24, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Pharmacological implications of MMP-9 inhibition by ACE inhibitors
Daisuke Yamamoto1, Shinji Takai
1Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatuski, Osaka 569-8686, Japan. center@art.osaka-med.ac.jp
Abstract:
Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.
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