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The utility of stable cell lines to assess species differences in PXR transactivation
Michael W Sinz1, Devin Pray, Judy Raucy
1Bristol-Myers Squibb Company, Wallingford, CT 06492, USA.
Drug Metabolism Letters
|April 10, 2009
Abstract:
A stable cell line was developed to assess activation of rat pregnane X receptor (rPXR) by xenobiotics. Characterization revealed that the greatest response occurred with dexamethasone (6-10 fold increase) while rifampicin failed to transactivate rPXR. Rodent PXR transactivation assays can be used to understand species differences in enzyme induction.
