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Identification of four urea adducts of andrographolide in humans

Liang Cui1, Wan Chan, Feng Qiu

  • 1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.

Drug Metabolism Letters
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PubMed

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Urea Cycle01:23

Urea Cycle

The urea cycle describes how liver cells convert ammonia to urea. Ammonia is a toxic waste product of protein catabolism. Land animals must convert ammonia into the less toxic urea which can be safely eliminated by the kidneys through urine. Marine animals excrete ammonia directly, and the surrounding water dilutes the ammonia to safe levels.