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Effectiveness of Jeryl Lynn-containing vaccine in Spanish children

Jesús Castilla1, Manuel García Cenoz, Maite Arriazu

  • 1Instituto de Salud Pública de Navarra, Pamplona, Spain. jcastilc@navarra.es

Vaccine
|April 10, 2009
PubMed

Insights

The Jeryl Lynn mumps vaccine showed 72% effectiveness overall, with two doses (83%) being more protective than one (66%). Early waning immunity may reduce protection over time, impacting mumps prevention efforts.

Area of Science:

  • Pediatrics
  • Immunology
  • Epidemiology

Background:

  • Mumps outbreaks can occur despite high vaccination rates.
  • The Jeryl Lynn strain vaccine is widely used for mumps prevention.
  • Understanding vaccine effectiveness during outbreaks is crucial for public health.

Purpose of the Study:

  • To evaluate the effectiveness of the Jeryl Lynn mumps vaccine during a large outbreak in Navarre, Spain.
  • To assess the impact of the number of vaccine doses on protection against mumps.
  • To identify factors influencing vaccine effectiveness, such as timing of vaccination.

Main Methods:

  • A case-control study design was employed, comparing 241 mumps cases with 5 individually matched controls.
  • Vaccination status was obtained from clinical records.
  • Conditional logistic regression was used to calculate matched odds ratios and vaccine effectiveness.

Main Results:

  • Overall vaccine effectiveness was 72% (95% CI, 39-87%).
  • Two doses of the measles-mumps-rubella (MMR) vaccine were more effective (83%) than a single dose (66%).
  • Vaccine effectiveness was lower when the first dose was given after 36 months or the second dose was administered 3+ years prior to the study.

Conclusions:

  • The Jeryl Lynn vaccine demonstrates moderate effectiveness against mumps, with two doses providing better protection.
  • Early waning of immunity after the second dose may contribute to reduced effectiveness over time.
  • Vaccination timing is a critical factor influencing protection against mumps.

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